Figure 2.

CeO₂ NP reduce fibrogenesis in TGF-β-activated cells. (a) Immunoblot analysis showed a dose-dependent reduction in both Col-I and α-SMA protein expression (n = 4). (b) RT-PCR analysis found Col-I expression in 500 µM CeO₂ NP and TiO₂ NP-treated cells to be significantly reduced (n = 3). (c) RT-PCR analysis found α-SMA expression in 100 µM CeO₂ NP, 500 µM CeO₂ NP and TiO₂ NP-treated cells to be significantly reduced (n = 3). Error bars represent SEM; ANOVA was used to calculate significance. * p < 0.05, *** p < 0.001.