Table 1.

Differentially expressed miRNAs in GC-secreting adrenal adenoma, in HeLa and H295R cells after glucocorticoid treatment and their connection with the elements of Wnt-signaling pathway (*—sclerostin domain-containing 1, **—based on pathway analysis Wnt-signaling is between the top targeted pathways). Log2FC indicates the direction and the extent of expressional change.

miRNA Name	log2FC	p-Value	Connection with Wnt-Signaling
Cortisol Producing Adenoma vs. Normal Adrenal Tissue			Targeted Gene(s)	References
hsa-miR-375-3p	−3.18283	0.002756	LRP5 and β-catenin	[30]
hsa-miR-566	−2.0934	0.012993	WNT6	[31]
hsa-miR-95-3p	0.435871	0.014638	DKK3	[32]
hsa-miR-506-3p	1.96571	0.021431	TCF3	[33]
hsa-miR-210-3p	−1.18389	0.038611	WNT7b, FZD5, Sclerostin	[34,35]
Dexamethasone Treated HeLa Cells vs. Control
hsa-miR-183-5p	0.203726	0.037677	LRP6, Dkk-3	[36,37]
hsa-miR-195-5p	1.355332	0.043846	LRP6, WNT3A	[38,39]
hsa-miR-26a-5p	1.321971	0.020827	SOSTDC1 *, Wnt5a, GSK3β	[40,41,42]
hsa-miR-30e-3p	−0.86986	0.02123	LRP6	[43]
hsa-miR-335-3p	1.586908	0.045771	RUNX2	[44]
hsa-miR-572	1.58437	0.042381	pathway analysis **	[45]
hsa-miR-622	3.287344	0.03071	pathway analysis **	[46]
hsa-miR-95-3p	2.307738	0.040524	DKK3	[32]
Dexamethasone Treated H295R Cells vs. Control
miR-331-5p	2.14926	0.018581	no literature data available
miR-7-1-3p	−0.25662	0.004913	TCF4, TCF12, TCF7L2	[47]
miR-27a-3p	0.457272	0.010971	DKK2	[48]
miR-346	0.921683	0.017707	GSK3β	[49]
miR-376a-3p	0.581655	0.034872	pathway analysis **	[50]
miR-668-3p	−0.56929	0.041363	no literature data available