Table 2.
Pathways regulated by differentially expressed miRNAs among different experiments. Common pathways are indicated by bolt letters.
| GC-Secreting Adrenal Adenoma | Hela Cells | H295R Cells | |||
|---|---|---|---|---|---|
| KEGG Pathway | p-Value | KEGG Pathway | p-Value | KEGG Pathway | p-Value |
| Biotin metabolism | 5.90E-06 | PI3K-Akt signaling pathway | 1.87E-26 | Focal adhesion | 5.71E-09 |
| Axon guidance | 5.90E-06 | Prostate cancer | 5.59E-20 | Wnt signaling pathway | 4.44E-08 |
| Long-term depression | 3.95E-04 | Wnt signaling pathway | 8.18E-14 | Neurotrophin signaling pathway | 4.44E-08 |
| Insulin signaling pathway | 3.23E-03 | mTOR signaling pathway | 5.65E-13 | ErbB signaling pathway | 1.08E-07 |
| Gap junction | 7.57E-03 | Insulin signaling pathway | 1.74E-12 | Gap junction | 1.08E-07 |
| Chronic myeloid leukemia | 8.75E-02 | Focal adhesion | 2.14E-11 | PI3K-Akt signaling pathway | 1.08E-07 |
| Glutamatergic synapse | 1.84E-01 | Ubiquitin mediated proteolysis | 8.16E-11 | GnRH signaling pathway | 1.85E-06 |
| Adipocytokine signaling pathway | 1.84E-01 | TGF-beta signaling pathway | 1.03E-10 | Circadian rhythm | 2.06E-05 |
| Wnt signaling pathway | 2.65E-01 | Pathways in cancer | 5.91E-10 | MAPK signaling pathway | 2.06E-05 |
| Gastric acids secretion | 2.65E-01 | Melanoma | 1.32E-09 | Ubiquitin mediated proteolysis | 3.30E-05 |
| Salmonella infection | 2.91E-01 | p53 signaling pathway | 1.69E-09 | Glioma | 5.05E-05 |
| Neurotrophin signaling pathway | 3.95E-01 | Regulation of actin cytoskeleton | 1.02E-08 | Long-term potentiation | 1.06E-04 |
| MAPK signaling pathway | 5.45E-01 | Glioma | 2.31E-08 | Pathways in cancer | 2.11E-04 |
| Retrograde endocannabinoid signaling | 6.21E-01 | Long-term potentiation | 2.58E-08 | Insulin signaling pathway | 2.58E-04 |
| ErbB signaling pathway | 6.21E-01 | Long-term depression | 2.76E-08 | mTOR signaling pathway | 2.08E-03 |
| TGF-beta signaling pathway | 6.77E-01 | Gap junction | 4.83E-08 | Axon guidance | 2.45E-03 |
| Pathways in cancer | 7.03E-01 | Endometrial cancer | 4.83E-08 | Dopaminergic synapse | 4.01E-03 |
| Acute myeloid leukemia | 9.43E-01 | Dopaminergic synapse | 5.80E-07 | Small cell lung cancer | 5.79E-03 |
| HTLV-I infection | 9.76E-01 | Fatty acid biosynthesis | 5.87E-07 | Lysine degradation | 6.25E-03 |
| GnRH signaling pathway | 1.34E+00 | Neurotrophin signaling pathway | 6.26E-07 | Protein processing in endoplasmic reticulum | 9.83E-03 |
| Shigellosis | 1.48E+00 | MAPK signaling pathway | 8.51E-07 | Prostate cancer | 2.00E-02 |
| Regulation of actin cytoskeleton | 1.86E+00 | Chronic myeloid leukemia | 4.10E-06 | TGF-beta signaling pathway | 2.13E-02 |
| Pancreatic cancer | 2.43E+00 | HIF-1 signaling pathway | 6.81E-06 | Amphetamine addiction | 6.20E-02 |
| Maturity onset diabetes of the young | 3.57E+00 | ErbB signaling pathway | 7.23E-06 | Hedgehog signaling pathway | 9.27E-02 |
| Cholinergic synapse | 4.00E+00 | Small cell lung cancer | 1.07E-05 | Chronic myeloid leukemia | 1.13E-01 |
| mTOR signaling pathway | 4.04E+00 | Non-small cell lung cancer | 4.37E-05 | RNA transport | 1.54E-01 |
| Focal adhesion | 4.79E+00 | Acute myeloid leukemia | 5.51E-05 | Melanogenesis | 2.37E-01 |
| Pancreatic secretion | 4.79E+00 | Prion diseases | 4.79E-04 | Regulation of actin cytoskeleton | 4.01E-01 |
| Non-small cell lung cancer | 5.54E+00 | mRNA surveillance pathway | 6.30E-04 | Renal cell carcinoma | 6.54E-01 |
| Salivary secretion | 7.96E+00 | Transcriptional misregulation in cancer | 1.48E-03 | Glutamatergic synapse | 6.54E-01 |
| Gastric acid secretion | 3.44E-03 | p53 signaling pathway | 9.56E-01 | ||
| Calcium signaling pathway | 6.18E-03 | Gastric acid secretion | 1.39E+00 | ||
| Aldosterone-regulated sodium reabsorption | 8.44E-03 | Biotin metabolism | 1.63E+00 | ||
| Hedgehog signaling pathway | 1.28E-02 | Transcriptional misregulation in cancer | 2.47E+00 | ||
| T cell receptor signaling pathway | 1.83E-02 | Bacterial invasion of epithelial cells | 4.44E+00 | ||
| RNA transport | 2.76E-02 | Fc gamma R-mediated phagocytosis | 7.41E+00 | ||
| Glutamatergic synapse | 3.14E-02 | Fc epsilon RI signaling pathway | 7.97E+00 | ||
| Renal cell carcinoma | 4.60E-02 | ||||
| Oocyte meiosis | 4.81E-02 | ||||
| Cell cycle | 4.89E-02 | ||||
| Biotin metabolism | 6.21E-02 | ||||
| Colorectal cancer | 1.11E-01 | ||||
| Basal cell carcinoma | 2.68E-01 | ||||
| Inositol phosphate metabolism | 2.68E-01 | ||||
| VEGF signaling pathway | 2.68E-01 | ||||
| B cell receptor signaling pathway | 2.68E-01 | ||||
| Pancreatic cancer | 2.68E-01 | ||||
| Cholinergic synapse | 3.50E-01 | ||||
| Melanogenesis | 3.72E-01 | ||||
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.19E+00 | ||||
| Hypertrophic cardiomyopathy (HCM) | 1.21E+00 | ||||
| Progesterone-mediated oocyte maturation | 1.21E+00 | ||||
| Apoptosis | 1.52E+00 | ||||
| Tight junction | 1.52E+00 | ||||
| Thyroid cancer | 1.52E+00 | ||||
| Viral carcinogenesis | 2.40E+00 | ||||
| Phosphatidylinositol signaling system | 2.41E+00 | ||||
| Bladder cancer | 2.65E+00 | ||||
| Cocaine addiction | 3.14E+00 | ||||
| Fanconi anemia pathway | 3.92E+00 | ||||