Table 6.

Gene expression profiling of glucocorticoid (GC) producing and target tissue types. (CS: Cushing syndrome, cortisol-producing adrenal adenoma; dex: dexamethasone; #: the munber of Controls).

Sample Type	Experiment	# of Control	# of Dex Treatment/GC Affected	DataSet [Refs]	Platform
Human tissue	bone tissue biopsies from CS patients, before vs. 3 months after surgery	9	9	GSE30159 [53]	Affymetrix Human Genome U133 Plus 2.0 Array
Human tissue	adrenal cortex, normal tissue vs. GC secreting adenoma	4	4	GSE14922 [51]	Agilent-014850 Whole Human Genome Microarray 4 × 44 K G4112F
In vitro human cell line	adrenocortical cancer (H295R) cell line, control vs. dex treatment	3	3	GSE64826 [52]	Affymetrix Human Gene 1.0 ST Array
In vitro human primary cells	osteoblast cell, control vs. dex	6	3	GSE21727 [54]	Illumina humanRef-8 v2.0 expression bead chip
In vitro human primary cells	osteoblast-like cells (HObs) from bone explant, control vs. dex treatment	6	3	GSE10311 [55]	Affymetrix Human Genome U133 Plus 2.0 Array
In vitro human primary cells	synovial fibroblasts, control or dex treatment	6	3	GSE37520 [56]	Applied Biosystems/University of Birmingham Human RT-PCR array (custom made)
In vitro human primary cells	abdominal subcutaneous adipose cells, control vs. dex treatment	3	3	GSE88966 [57]	Affymetrix Human Gene 1.0 ST Array
In vitro human primary cells	abdominal omental adipose cells, control vs. dex treatment	3	3	GSE88966 [57]	Affymetrix Human Gene 1.0 ST Array
In vitro human primary cells	epidermal keratinocytes, control vs. dex treatment	2	2	GSE26487 [58]	Affymetrix Human Genome U95 Version 2 Array
German Landrace piglet tissue	7-week old purebred piglet hippocampus tissue, control vs. im. dex treatment	20	12	Murani et al., 2021 [74]	TruSeqStranded mRNA sample preparation kit; HiSeq 2500 instrument
German Landrace piglet tissue	7-week old purebred piglet hypothalamus tissue, control vs. im. dex treatment	20	12	Murani et al., 2021 [74]	TruSeqStranded mRNA sample preparation kit; HiSeq 2500 instrument