Skip to main content
. 2021 Oct 27;22(21):11611. doi: 10.3390/ijms222111611

Figure 5.

Figure 5

Schematic depicting the experimental design. (A) S1R-/- and WT mice were subjected to latFPI, and behavioral outcomes were assessed for up to 12 months postinjury. (B) BD-1063 was administered to evaluate the effects of pharmacological blockade of S1R. Behavioral outcomes were evaluated for up to 7 days postinjury. Brain tissues were collected from animals in both experiments for histological analysis at the end point. TBI—traumatic brain injury, NSS—neurological severity score, RR—rota-rod, TSE—PhenoMaster behavioral phenotyping.