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. 2021 Oct 22;22(21):11398. doi: 10.3390/ijms222111398

Figure 2.

Figure 2

Figure 2

NLRP12 negatively regulates innate immune signaling in a pathogen-dependent manner. (A) NLRP12 inhibits IRAK1 and TRAF3/NIK to further inhibit canonical and noncanonical NF-κB signaling and the MAPK/ERK inflammatory signaling pathway in bone marrow-derived macrophages (BMDMs). (B) NLRP12 participates in the recruitment of ASC for the processing of caspase 1 and maturation of IL-1β and IL-18 to positively regulate innate host defense during Yersinia pestis and Plasmodium chabaudi. (C) NLRP12 associates with TRIM25 to reduce polyubiquitination of RIG-I and inhibits the RIG-I-mediated IFN response during VSV infection in bone marrow-derived dendritic cells. RIG-, Retinoic acid-inducible gene I; MAVS, Mitochondrial antiviral-signaling protein; TBK1, TANK-binding kinase 1.