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. 2021 Oct 28;22(21):11660. doi: 10.3390/ijms222111660

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Immortalization can be induced by the expression of telomerase or factors inactivating or bypassing p53/p16/Rb. Reproduced with permission from Maqsood et al., Cell Biology International; published by Wiley Online Library, 2013.