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. 2021 Oct 29;22(21):11738. doi: 10.3390/ijms222111738

Figure 5.

Figure 5

Mitophagy evaluation on 3T3-L1 adipocytes exposed to CDCA in the absence or presence of TGR5. (A) Gene expression of mitodynamics-involved proteins mitofusins 1 and 2 (mfn1 and mfn2) and fission protein 1 (fis1); (B) Protein content of several players involved in mitophagy and mitochondrial fission and fusion. DLP1—Dynamin-like protein 1; Mfn1—Mitofusin 1; LC3—Light chain 3B; Mfn2—Mitofusin 2. Data are derived from 3 independent experiments, and bars represent means ± SEM. * indicates a statistically significant difference vs. Control (p < 0.05); % indicates a statistically significant difference vs. CDCA (p < 0.05); & indicates a statistically significant difference vs. Cas9 (p < 0.05).