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. 2021 Oct 26;22(21):11530. doi: 10.3390/ijms222111530

Figure 1.

Figure 1

6-OHDA intrastriatal lesion effects on motor behavioral tasks. Overall, all performed tests were found to be sensitive to DA-depleting lesions of the nigrostriatal pathway, 3 and 11 weeks after intrastriatal 6-OHDA injections. 6-OHDA-lesioned mice presented significant impairments in general motor paradigms observed after beam balance (a), motor swimming (b) and pole (c) tests evaluation. The cylinder test (d) revealed that 6-OHDA animals use the left (lesioned) forelimb significantly less when compared to the vehicle group (Student’s t-test; statistical summary in Table S1; data are presented as mean ± SEM). At the open arena (e), it was observed that 6-OHDA injections had a negative impact on the horizontal exploratory activity and animal’s gait quality. The rotameter test (f) revealed the success of intrastriatal 6-OHDA lesions with the majority of animals displaying turning behavior after apomorphine administration (Mann–Whitney U test; statistical summary Table S1; data are presented as mean ± IQR). Vehicle n = 19–20, 6-OHDA n = 23–26; except for cylinder test—vehicle n = 8–9, 6-OHDA n = 8–10. * p < 0.05, *** p < 0.001. Abbreviations: 6-OHDA, 6-hydroxydopamine.