Figure 2.

Impact of 6-OHDA intrastriatal lesion on anxiety- and depressive-like behavior. Compared to vehicle, 6-OHDA-lesioned group showed no signs for increased anxiety as seen by the similar time in the center of the OF arena (a) and the similar time in the open arms of the EPM (b). Regarding depressive-like behavior, in FST (c) 6-OHDA-lesioned mice displayed less time immobile but had an increase in time they spent grooming in SST (d), when compared to the vehicle group (Student’s t-test; statistical summary in Table S1; data are presented as mean ± SEM). Vehicle n = 17–19, 6-OHDA n = 24–26. * p < 0.05. Abbreviations: EPM, elevated-plus maze; FST, forced swim test; OF, open field; SST, splash-sucrose test; 6-OHDA, 6-hydroxydopamine.