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In HeLa cells, SRSF1 promotes exon skipping in Ich-1 to produce the pro-apoptotic Ich-1L isoform. However, in HEK 293 cells, SRSF1 promotes the expression of Bcl-xL, the anti-apoptotic isoform of Bcl-x, by favoring a distal 5′ splice site. miR-28 and miR-505 directly target the 3′UTR of SRSF1, and the result induces a shift of the isoform ratios of Ich-1 and Bcl-x.
