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Hyperglycemia-induced nephrin modification induces glomerulosclerosis. Ac: acetylation; Dnmt1: DNA methyltransferase 1; EndMT: endothelial-to-mesenchymal transition; HDAC4: histone deacetylase 4; IL-1β: Interleukin-1β; KDM6A: lysine-specific demethylase; KLF 10: Krϋppel-like factor 10; Me: methylation; TGF-β: Transforming growth factor β; Ub: ubiquitination; WT1: Wilms’ tumor 1 protein. ↑: Increase in the expression level; ↓: Decrease in the expression level.
