Table 1.

Adult neurogenesis in the SVZ.

Species	Age/ Sex	Manipulation/ Treatment	Proliferation/ Differentiation	Maturation/ Survival	Protein/Gene/Growth factor	Function	Effect on the SVZ	References
Sprague-Dawley	PND 1–3	BDNF (30 ng/mL)	Sox2 NeuN		BDNF		Role in migration	[34]
		TrkB-Fc (2 μL/mL)					TrkB has roles in migration, signaling, synaptic formation, maturation and plasticity
CDI mice	Newborn (PND 4–10) Young adult (1–2 months)	Culture medium supplemented with BDNF (50 ng/mL) or with an inhibitor.	GFAP TrkB				Mediate migratory signals	[35]
Wistar rats	Adult/ Male	SAH	Ki67 DCX GFAP				Regulation of neurogenesis after a neurological event	[36]
Qkf-GFP transgenic mice	PND 49–120	Untreated	GFAP CD24		KAT6B gene	Important role in adult neurogenesis	High expression in the SVZ	[37]
Btg1 knockout mice	PND 7– 2 months/ Male	Untreated	GFAP DCX NeuN Nestin BrdU Ki67		Btg1 gene	Cell cycle inhibitory gene	Required for the proliferation, maintenance and self-renewal of NSCs	[38]
Wistar rats	PND 1	Astrocytes isolated from the cerebral cortex Untreated	GFAP bFGF		FGF-2 Epidermal growth factor		Promotes the astrocyte hypertrophic morphology and proliferation.	[39]
Wild-type CD1 Mice	PND 30–60/ Male	Untreated	BrdU DCX		5HT and serotoninergic transmission		Critical role in proliferation. 5HT increases the proliferation of B1 cells through the activation of 5HT2Cr.	[40]
Transgenic mice	PND 14–41	Untreated	GFAP		GABA		GABA controls neuroblast proliferation through GABAA	[41]

5HT: serotonin; FGF-2: fibroblast growth factor-2; bFGF: basic fibroblast growth factor; SAH: subarachnoid hemorrhage.