Table 7.

Summary of adult human neurogenesis studies.

Age (Years)	Sample Number	Source	Tissue Preparation	Proliferation Marker	Cell Fate Markers	References
57–72	5	Postmortem tissue	24 h postfixed with 4% paraformaldehyde and then transferred to a 30% sucrose solution	BrdU	NeuN Calbindin GFAP	[3]
1 day–100 years	3 fetal 49 brains 1 resection	Postmortem tissue Postmortem tissue Lobectomy	Paraffin sections Not described Not described	PCNA Ki67	DCX Nestin BLBP NeuroD Prox 1 Sox2 PSN-NCAM Calretinin Calbindin GAD65 GAD67 TUC4 β-III-tubulin Map2ab	[260]
14–79	28 brains	Postmortem tissue	Coronal blocks were flash-frozen in liquid Freon (−20 C°) and stored at −80 °C. The tissue samples were fixed with formalin. For processing, the hippocampus was dissected from the blocks, fixed with 4% paraformaldehyde at 4 °C and then cryoprotected in 30% sucrose	Ki-67	Nestin DCX PSA-NCAM Sox2	[103]
18–77	17 brains 12 surgically resected tissues from patients with epilepsy as controls	Postmortem tissue Lobectomy		Ki-67	DCX PSA-NCAM NeuN	[261]
43–87 40–100	17 healthy subjects to establish neurogenesis 13 healthy control subjects 45 patients with AD	Postmortem tissue postmortem tissue	Tissues were stored in 4% PFA at 4 °C for 24 h Tissues were stored in 4% PFA at 4 °C for 24 h		DCX NeuN Prox1 PH3 Calretinin Calbindin DCX	[4]