Table 2.

Results of pathway analysis using IPA (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis, accessed on 20 April 2021). Shown are activation z-scores and –log p-values of the top 15 canonical pathways in cell pellet (CP) samples after transfection (n = 3). Z-scores ± 2 are considered significant. Positive z-scores indicate activation, while negative values show inhibition of the corresponding pathway.

	Ingenuity Canonical Pathways	–log (p-Value)	z-Score
Top 15 canonical pathways (p-value)	EIF2 Signaling	45.5	2.21
	Oxidative Phosphorylation	23	2.36
	Inhibition of ARE-Mediated mRNA Degradation Pathway	22.1	−1.66
	Regulation of eIF4 and p70S6K Signaling	21.9	−1.83
	mTOR Signaling	18.9	−1.66
	Spliceosomal Cycle	18.5	2.34
	Remodeling of Epithelial Adherens Junctions	16	−2.13
	Coronavirus Pathogenesis Pathway	13.3	−1.61
	Sumoylation Pathway	10	1.72
	Integrin Signaling	9.85	−2.24
	14-3-3-mediated Signaling	8.06	−2.29
	Ephrin Receptor Signaling	7.11	−1.83
	VEGF Signaling	7.01	−1.72
	Ferroptosis Signaling Pathway	6.7	−2.18