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4D imaging of local doxorubicin delivery in murine tumors using the developed MI-MD system. (a) Drug loading diagram and the delivery processes captured by the MI-MD system. Dimensions of the FOV and orientation of the imaging probe relative to the FOV are identical to those in Figure 3b. (b) Variation of the overall fluorescence signal for both the doxorubicin compound and pure PEG and (c) their ratio as a function of time.
