Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Overview of genetic events linked to treatment resistance strategies in glioblastoma malignancies. Mutagenetic events inducing constitutive (A) PI3K and (B) EGFR activity lead to increased tumor growth, proliferation, metabolism and angiogenesis [21,23,24,31,32,33]. (C) Mutations in substrate-binding active sites of IDH1 and IDH2 impede histone demethylation pathways, altering gene regulation and contributing to tumorigenesis [27,28].
