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Schematic representation of the AQP channel structure. (A). View of the extracellular face of tetrameric AQP1, based on X-ray crystal structure for bovine AQP1 (Protein Data Bank 1J4N). (B). Membrane topography of an individual subunit with 6 helical transmembrane domains (M1-M6) connected by loops A to E. (Inset 1) View of Pro 79, Asp 80 and Asn 78 residues of the signature NPA motif. (Inset 2) View of His 182, Phe 58 and Arg 197 residues of the ar/R constriction selectivity filter.
