Table 1.
Patient characteristics of AS and OA controls.
| AS Patients (n = 193) | OA Controls (n = 74) | |
|---|---|---|
| Patient characteristics | ||
| Gender, male (n, %) | 138 (72) | 43 (58) |
| Age, years (mean ± SD) | 60 ± 7 | 62 ± 7 |
| Race, Caucasian (n, %) | 162 (84) | 65 (88) |
| BMI, kg/m2 (mean ± SD) | 26.6 ± 4.1 | 28.6 ± 5.5 |
| BSA, m2 (mean ± SD) | 1.9 ± 0.2 | 2.0 ± 0.2 |
| Blood pressure, mmHg | ||
| Systolic (mean ± SD) | 134 ± 16 | 133 ± 17 |
| Diastolic (mean ± SD) | 84 ± 8 | 82 ± 9 |
| CVD risk factors | ||
| Smoking status | ||
| current (n, %) | 39 (20) | 15 (20) |
| ever (n, %) | 98 (51) | 35 (47) |
| never (n, %) | 55 (29) | 24 (32) |
| pack years (median, IQR) | 28 (14–37) | 12 (6–31) |
| Obesity (n, %) | 42 (22) | 26 (35) |
| Hypertension (n, %) | 118 (61) | 45 (61) |
| Hypercholesterolemia (n, %) | 36 (19) | 22 (30) |
| Diabetes Mellitus type II (n, %) | 22 (11) | 10 (14) |
| Total history CVD (n, %) | 21 (11) | 8 (11) |
| Angina Pectoris (n, %) | 5 (3) | 2 (3) |
| Myocardial infarction (n, %) | 12 (6) | 4 (5) |
| Stroke | ||
| TIA (n, %) | 4 (2) | 3 (4) |
| CVA (n, %) | 3 (2) | 0 (0) |
| Peripheral ischemia (n, %) | 1 (1) | 1 (1) |
| CABG (n, %) | 8 (4) | 2 (3) |
| Family history (first degree) | ||
| AP/MI (n, %) | 24 (12) | 11 (15) |
| Stroke/TIA (n, %) | 14 (7) | 6 (8) |
| Laboratory | ||
| LDL, mmol/L | 3.3 ± 0.9 | 3.5 ± 1.1 |
| HDL, mmol/L | 1.5 ± 0.4 | 1.3 ± 0.4 |
| Cholesterol/HDL ratio | 3.8 ± 1.6 | 4.2 ± 1.7 |
| ESR, mm/h | 7.5 (4.0–10.0) | 5.0 (2.0–11) |
| CRP, mg/L | 2.8 (1.1–7.8) | 1.6 (0.8–3.1) |
| Medication | ||
| Antihypertensives (n, %) | 85 (44) | 20 (27) |
| Lipid-modifying drugs (n, %) | 40 (21) | 19 (26) |
| NSAIDs (n, %) | 108 (56) | 37 (50) |
| Anti-TNF drugs | ||
| current (n, %) | 70 (36) | N.A. |
| ever (n, %) | 13 (7) | N.A. |
| naive (n, %) | 110 (57) | N.A. |
Values are displayed as mean ± standard deviation (SD), median with corresponding interquartile range (IQR) or frequencies with corresponding percentages (%). AS = ankylosing spondylitis, OA = osteoarthritis, BMI = body mass index, BSA = body surface area, CVD = cardiovascular disease, TIA = transient ischemic attack, CVA = cerebrovascular attack, CABG = coronary artery bypass graft, AP = angina pectoris, MI = myocardial infarction, NSAIDs = non-steroidal anti-inflammatory drugs, anti-TNF = anti-tumor necrosis factor, N.A. = not applicable. Normal ranges for laboratory assessments: LDL 2.0–4.5 mmol/L, HDL 0.9–1.7 mmol/L, ESR in men > 50 years < 20 mm/h, ESR in women > 50 years < 30 mm/h, CRP < 10 mg/L.