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. 2021 Nov 5;22(21):11985. doi: 10.3390/ijms222111985

Figure 1.

Figure 1

Naringenin improved the macroscopic morphology of gastric damage induced by ethanol in mice. C57BL/6 mice were randomly assigned to 5 different groups (6 mice per group). The vehicle (10% dimethyl sulfoxide (DMSO) and 90% glyceryl trioctanoate), naringenin (Nar, 10 and 20 mg/kg) and omeprazole (OMEP, 20 mg/kg; used as a positive control) were given orally for a period of 3 days. After fasting for 12 h prior to the experiment, mice were fed orally with ethanol (0.5 mL/100 g body weight) to induce the acute ulcer. After 4 h, mice were sacrificed. In the normal control group, the mice only received vehicle (Normal). (A) Representative photos of the dissected stomach. (B) The scores for macroscopic gastric damage. The data obtained from individual animal samples per group were averaged (n = 6); values represent mean ± standard deviation (SD). Statistical comparison was analyzed by a one-way ANOVA followed by Tukey’s multiple comparison tests. Bars not sharing a common letter represent a statistically significant difference (p < 0.05).