TABLE 2.
Sensitivity of mSNM1−/− and ERCC1−/− ES cells to various genotoxic agents
| Genotoxic agent | Dose | Sensitivitya of the following cells:
|
|
|---|---|---|---|
| mSNM1−/− | ERCC1−/− | ||
| MMC | 0.1–1.6 μg/ml | Sens | Sens |
| Melphalan | 0.5–12 μM | Wt | ND |
| 8-Methoxypsoralen plus UVA light | 0.1–100 ng/ml | Wt | Sens |
| Cisplatin | 0.25–4 μg/ml | Wt | Sens |
| Gamma rays | 1–8 Gy | Wt | Wt |
| Methyl methanesulfonate | 1–2.5 mM | Wt | Wt |
| UV254 nm | 2–12 J/m2 | Wt | Sens |
a
Wt, sensitivity equal to that of wild-type cells; Sens, sensitivity higher than that of wild-type cells; ND, sensitivity not determined.