AEs |
adverse events |
ALK |
anaplastic lymphoma kinase |
AST |
aspartate aminotransferase |
ATA |
American Thyroid Association |
ATC |
anaplastic thyroid cancer |
BMI |
body mass index |
BRAF |
B-Raf proto-oncogene |
CT |
computer tomography |
CTLA-4 |
cytotoxic T-lymphocyte antigen-4 |
DeTC |
dedifferentiated thyroid cancer |
DIT |
diiodotyrosine |
DTC |
differentiated thyroid cancer |
EBRT |
external beam radiation therapy |
eIF1A |
eukaryotic translation initiation factor 1A |
EMA |
European Medical Agency |
FAP |
familial adenomatous polyposis |
FDA |
Food and Drug Administration |
18FDG |
18F-fluoro-2-deoxy-D-glucose |
FNAB |
fine-needle aspiration biopsy |
FTC |
follicular thyroid carcinoma |
FVPTC |
follicular variant of PTC |
GTP |
guanosine triphosphate |
HCC |
Hürtle cell carcinoma |
HNHA |
N-hydroxy-7-(2-naphthylthio) heptanamide |
HT |
hypertension |
IDH1 |
isocitrate dehydrogenase 1 |
IDH2 |
isocitrate dehydrogenase 2 |
IMRT |
intensity-modulated radiation therapy |
KIs |
kinase inhibitors |
MAPK |
mitogen-activated protein kinase |
MEN |
multiple endocrine neoplasia |
MEN2 |
multiple endocrine neoplasia type 2 |
MIT |
monoiodotyrosine |
MKIs |
multi-kinase inhibitors |
MRI |
magnetic resonance imaging |
MTC |
medullary thyroid cancer |
ND |
not defined |
NIS |
sodium iodide symporter |
ORR |
overall response rate |
OS |
overall survival |
PAX8 |
paired box 8 |
PD |
progressive disease |
PDCT |
poorly differentiated thyroid carcinoma |
PET |
positron emission tomography |
PFS |
progression-free survival |
PI3K |
phosphatidylinositol 3-kinase |
PIK3CA |
phosphatidylinositol-4,5-bisphosphate 3-kinase |
PLC-γ |
phospholipase C |
PPARγ |
peroxisome proliferator activated receptor γ |
PPES |
palmar-plantar erythrodysesthesia syndrome |
PR |
partial response |
PTC |
papillary thyroid carcinoma |
RAI |
radioactive iodine; radioiodine |
RAIR |
radioactive iodine refractory; radioiodine refractory |
RANKL |
receptor activator of nuclear factor κ-Β ligand |
RETf |
RET fusion-positive |
RETm |
RET mutation-positive |
RTK |
receptor tyrosine kinase |
RWS |
Real-Word Studies |
SD |
stable disease |
SKIs |
specific kinase inhibitors |
T3 |
triiodothyronine |
T4 |
thyroxine |
TBSRTC |
The Bethesda System for Reporting Thyroid Cytopathology |
TC |
thyroid cancer |
TCGA |
The Cancer Genome Atlas |
TERT |
telomerase reverse transcriptase |
Tg |
thyroglobulin |
THs |
thyroid hormones |
TPO |
thyroid peroxidase |
TRK |
tropomyosin receptor kinase |
TSH |
thyroid-stimulating hormone |
USG |
ultrasonography |
WBC |
white blood cell |
WHO |
World Health Organization |
wt |
wild type |