Table 2.
Incidence of first hospitalisation for cardiovascular reasons in primary Sjögren’s syndrome patients and controls.
| pSS Patients | Matched Controls | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Incident Cases # | Py | Incidence # | CI | Incident Cases # | Py | Incidence # | CI | Crude HR | Crude CI | Crude p Value | aHR | Adjusted CI | Adjusted p Value | |
| Cardiovascular events | ||||||||||||||
| Ischemic heart disease | 535 | 98611 | 5.43 | (4.97–5.89) | 3723 | 967246 | 3.85 | (3.73–3.97) | 1.39 | (1.27–1.52) | 0.000 | 1.20 | (1.06–1.34) | 0.003 |
| Stroke | 227 | 101241 | 2.24 | (1.95–2.53) | 2159 | 1000199 | 2.16 | (2.07–2.25) | 1.01 | (0.88–1.16) | 0.845 | 1.05 | (0.88–1.25) | 0.606 |
| Heart failure | 486 | 100321 | 4.84 | (4.41–5.27) | 3339 | 991590 | 3.37 | (3.26–3.48) | 1.42 | (1.29–1.56) | 0.000 | 1.05 | (0.92–1.19) | 0.497 |
| Cardiovascular risk factors | ||||||||||||||
| Hypertension | 137 | 101508 | 1.35 | (1.12–1.58) | 807 | 1008796 | 0.8 | (0.74–0.86) | 1.71 | (1.42–2.05) | 0.000 | 1.39 | (1.07–1.80) | 0.014 |
| Sleep apnoea syndrome | 438 | 99839 | 4.39 | (3.98–4.8) | 1645 | 995874 | 1.65 | (1.57–1.73) | 2.66 | (2.39–2.95) | 0.000 | 1.97 | (1.70–2.28) | <0.001 |
| Venous thromboembolic events | ||||||||||||||
| Pulmonary embolism | 131 | 101747 | 1.29 | (1.07–1.51) | 887 | 1011218 | 0.88 | (0.82–0.94) | 1.45 | (1.21–1.75) | 0.000 | 1.10 | (0.86–1.41) | 0.460 |
| All vein thromboses | 214 | 101027 | 2.12 | (1.84–2.4) | 1400 | 1002691 | 1.4 | (1.33–1.47) | 1.50 | (1.30–1.73) | 0.000 | 1.04 | (0.85–1.27) | 0.701 |
| Pulmonary hypertension | 72 | 102319 | 0.70 | (0.54–0.86) | 126 | 1019457 | 0.12 | (0.10–0.14) | 5.72 | (4.27–7.68) | 0.000 | 3.32 | (2.10–5.25) | <0.001 |
pSS, primary Sjögren’s syndrome; CI, confidence interval; py, person-years; # number of incident cases per 1000 person-years; HR, hazard ratio; aHR, adjusted HR. Bold is significance of p value.