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. 2021 Oct 31;22(21):11834. doi: 10.3390/ijms222111834

Figure 6.

Figure 6

Effect of FBLN2 on both cell lysate and exosome-derived miRNAs. (a) Nine miRNAs were widely expressed in cell lysates of both H1299 and H2170 cells, but in different expression patterns. Compared to mock transfectants, miR-29a-3p, miR-29b-3p, miR-9-3p, miR-200b-3p, and miR-125b-5p were highly expressed in H2170 FBLN2 transfectants, while miR-1-3p, miR-199-5p, miR-125b-5p, and miR-21-5p were upregulated in H1299 transfectants. miRNA expression level normalized to U6 in the mock cells was set to 1.0. * p < 0.05, ** p < 0.01, *** p < 0.001. (b) In the analysis of exosome-derived miRNA, FBLN2 overexpression upregulated the expression of miR-29a-3p, miR-200b-3p, miR-155b-5p, and miR-125b-5p in both cell lines, and the expression of miR-29b-3p and miR-21-5p in H1299. miRNA expression level normalized to cel-miR-39 in the mock cells was set to 1.0., * p < 0.05, ** p < 0.01.