Table 5.
Simultaneous influence of the indipendent variables (the level of methylation levels of the genome regions related to SYT2, GCSAML, GRM2, DRD3, NR3C1, TRPA1, MIR129-2, IL25, TNFRSF13B, OXT, MCF2, depression measured through BDI questionnaire, and the demographic grouped factors) on the risk to have FM. Logistic multivariate regression model—explanatory variables: mean methylation levels, BDI, Cluster Two Factors; dependent variable: FM.
| Logistic Regression | ||||||
|---|---|---|---|---|---|---|
| Dependent Variable: Fibromyalgia | ||||||
| Variables in the Equation | Odds Ratio | Robust Std. Err. | z | p > |z| | [95% Conf. Interval] | |
| SYT2 | 4.919 | 6.950 | 1.13 | 0.260 | 0.308 | 78.461 |
| GCSAML | 1.038 | 0.162 | 0.24 | 0.808 | 0.765 | 1.410 |
| GRM2 | 0.614 | 0.143 | −2.09 | 0.037 | 0.388 | 0.971 |
| DRD3 | 3.035 | 12.078 | 0.28 | 0.780 | 0.001 | 7413.646 |
| NR3C1 | 0.006 | 0.020 | −1.45 | 0.147 | 5.17 × 10−6 | 6.157 |
| TRPA1 | 12.892 | 22.999 | 1.43 | 0.152 | 0.391 | 425.457 |
| MIR1292 | 0.091 | 0.162 | −1.35 | 0.178 | 0.003 | 2.984 |
| IL25 | 2.279 | 3.888 | 0.48 | 0.629 | 0.080 | 64.565 |
| TNFRSF13B | 7.145 | 15.473 | 0.91 | 0.364 | 0.102 | 498.124 |
| OXT | 1.115 | 0.533 | 0.30 | 0.761 | 0.464 | 2.854 |
| MCF2 | 1.162 | 0.238 | 0.73 | 0.465 | 0.777 | 1.736 |
| Depression—BDI | 1.366 | 0.108 | 3.95 | 0.000 | 1.170 | 1.594 |
| Demographic factors—Cluster Two steps | 2.209 | 2.061 | 0.85 | 0.396 | 0.355 | 13.757 |
| _cons | 3.09 × 10−17 | 8.07 × 10−16 | −1.45 | 0.146 | 1.68 × 10−39 | 567324.4 |
| Number of obs. = 65 | ||||||
| Log pseudolikelihood = −19.74235 | Wald chi2 (7) = 32.48 | |||||
| Prob > chi2 = 0.0020 | ||||||
| Pseudo R2 = 0.5611 | ||||||