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Regulation of vascular tone by arachidonic acid metabolites. Arachidonic acid metabolites produced in endothelial cell (EC) including prostaglandin (PG)D2, PGE2, PGF2α, prostacyclin (PGI2), and thromboxanes (TX)A2 target to their corresponding receptor in smooth muscle cell (SMC), increasing intracellular cAMP level [cAMP]i to induce relaxation or decreasing intracellular calcium level [Ca2+]i to induce contraction.
