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. 2021 Nov 8;22(21):12063. doi: 10.3390/ijms222112063

Figure 1.

Figure 1

Clioquinol (CQ) does not affect cell viability at low doses. (A) Low dose (0.1 to 10 μM) of CQ did not cause morphological changes in M1C cells, but at a concentration of 100 µM, it was overtly toxic to cells. (B) The effects of CQ on M1C cell survival following TetOff induction of tau expression was examined by the ATP assay. The LD50 value obtained from the ATP assay was 80 µM CQ for M1C cells, and the reduced viability was significant at 100 µM. Data are the relative change compared with the control (1). NI: non-induced cells without CQ, n = 4, data are presented with ± SD, ** p < 0.01, versus vehicle control, as determined by ANOVA. N.S.: not significant.