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. 2021 Nov 8;22(21):12063. doi: 10.3390/ijms222112063

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Clioquinol (CQ) decreased tau levels detected using non-phospho dependent Tau5 in M1C cells. M1C cells were exposed to CQ at 0, 1, or 5 μM during the final day of induction. (A) Lysates derived from cultures were immunoblotted with antibody against Tau5. CQ decreased the total amount of tau. n = 7, ** p <0.01, * p <0.05, Bar: ± SD. (B) CQ did not alter tau mRNA levels according to quantitative real-time PCR (qPCR). Data are the relative change compared with the control. n = 3, Bar: ± SD, ns—not significant. Data from Tau5/GAPDH, and mRNA Tau/GAPDH followed a normal distribution and were analyzed by one-way ANOVA followed by the Bonferroni post hoc test.