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. 2021 Nov 11;17(11):e1009876. doi: 10.1371/journal.pgen.1009876

Fig 3. High PI3K signaling and stemness scores, but not PIK3CA mutations, are enriched in aggressive breast cancer subtypes.

Fig 3

(A) PI3K signaling score distribution in METABRIC breast tumors stratified according to ER status. (B) PI3K signaling and stemness score distributions across METABRIC breast cancers stratified according to PAM50 subtype; ** p ≤ 0.01, *** p ≤ 0.001 according to Tukey’s Honest Significant Differences method. (C) and (D) The distribution of PIK3CA wild-type (PIK3CA.WT) and mutant (PIK3CA.MUT) samples in METABRIC breast cancers, stratified according to ER status (C) or PAM50 subtype (D).