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. 2021 Nov 3;10(21):5156. doi: 10.3390/jcm10215156

Table 1.

Patient, intervention/exposure, comparator, outcome, study design (PICOS) criteria for inclusion and exclusion of studies.

Parameter Inclusion Criteria Exclusion Criteria
Population Healthy adults Children and adolescents, individuals with any specific physical health problems, intellectual disabilities, eating disorders, or neurological disorders
Intervention/exposure Participants assessed during vitamin D supplementation Combined multiple nutrients supplemented
Comparison Influence on a mental health outcomes assessed while compared with baseline/placebo/various doses and regimens Lack of comparison
Outcome Any aspect of mental health associated with any area of the broad spectrum of general mental health Patients assessed for cognitive function
Study design Peer-reviewed articles published in English, including: randomized controlled trials, randomized crossover trials, cohort studies, case-control studies, and cross-sectional studies Articles not published in English, reviews, meta-analyses, expert opinions, letters to editor, comments, studies in animal models, methodological articles, case reports, and conference reports