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. 2021 Oct 20;10(21):4801. doi: 10.3390/jcm10214801

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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IL-6 levels at 1 and 3 days after laser-induced ocular hypertension (OHT). (a) The IL-6 values obtained in the multiplex assay. The histogram shows the mean levels (±SD) of IL-6 (pg/mg) at days 1 and 3 after laser OHT induction in saffron ocular hypertension eyes (saffron OHT), saffron-contralateral eyes (saffron-contralateral), and saffron-naïve eyes. Statistical significance indicators: * p < 0.05. (b) Immunohistochemical study of IL-6 expression in saffron OHT eyes one day after unilateral laser-induced OHT. Retinal sections were immunolabeled with antibodies to IL-6 (green) and Iba-1 (red). Merge is denoted by the colour yellow. The arrowhead shows the co-expression of Iba-1 and IL-6 in saffron OHT and saffron-naïve eyes. Abbreviations: OHT (ocular hypertension); IL-6 (interleukin 6); Iba-1 (ionized calcium-binding adaptor molecule).