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. 2021 Nov 5;22(21):11984. doi: 10.3390/ijms222111984

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cytotoxic effects of the combination of CLZ with (A,B) BenzoTZ-C2-CPP2, (C,D) NTZ-C2-CPP2, (E,F) MTZ-C2-CPP2 and (G,H) BTZCA-CPP2 on the viability (right panel) and cell protein (left panel) content of PC-3 cells. Cell viability and protein content were assessed by MTT and SRB assays, respectively, after 48 h of exposure to each treatment. Results are expressed in the percentage of cell viability relative to the untreated control cells. *, **, *** and **** indicate p < 0.05, p < 0.01, p < 0.001 and p < 0.0001, respectively, when compared to the control. All data are presented as the mean ± SEM of three independent experiments.