Table 3.
In vitro studies of the ubiquitin inhibitors supporting the suppression of tumors.
| S. No. | Drugs | Category | Cell Lines | Reference |
|---|---|---|---|---|
| 1. | Largazole | Ubiquitin activating enzyme (UAE) inhibitor | Kip16, a GFP-p27 expressing Cell Line | [191] |
| 2. | Himeic acid A | UAE inhibitor | Western blotting with anti-Flag antibody | [192,193] |
| 3. | Ub-vinylsulfonamide (Ub-AVSN) | UAE inhibitor | N597A variant and the WT assay | [194,195] |
| 4. | Pimozide or GW7647 | USP1/UAF1 inhibitor | H596 and H460 cell lines | [196] |
| 5. | Leucettamol A | Ubc13-Uev1A inhibitor | Escherichia coli BL21 cells | [197] |
| 6. | NSC697923 | Ubc13-Uev1A inhibitor | ABC (activated B cell-like)-DLBCL cells and GCB (germinal center B cell-like)-DLBCL cells | [198] |
| 7. | Manadosterols A and B | Ubc13-Uev1A inhibitor | Escherichia coli BL21 cells | [199] |
| 8. | Vitexin | ubiquitin-conjugating enzyme E2-25K inhibitor | Rat pheochromocytoma PC12 cells, HepG2 (human hepatocellular carcinoma), and HOS (human osteosarcoma) cells | [200] |
| 9. | HLI98 family (C, D, E) | Ubiquitin ligase enzyme inhibitor | SAOS cells | [201] |
| 10. | RKTS-80, -81, -82 | E1 inhibitors | human breast cancer MCF-7 cells | [202] |
| 11. | Physalin B | proteasome inhibitors | human DLD-1 colon cancer cells | [203] |
| 12. | HLI-373 | E3 ligase inhibitor | ovarian SKOV3 cells | [204] |
| 13. | ONX-0914 | Immunoproteasome inhibitors | KMS-11 cells | [205] |
| 14. | PR-924 | Immunoproteasome inhibitor | Human T-cell ALL CCRF-CEM cells, human myeloid leukemic THP1 cells, and human multiple myeloma RPMI-8226 cells | [206] |
| 15. | Capzimin | Proteasome inhibitor | HCT116 cell lines | [207] |
| 16. | QCBT7 | Proteasome inhibitor | colon carcinoma cell line HCT 116. | [208] |
| 17. | IU1-47 | USP14 inhibitor | A549 and H1299 cell lines | [209] |
| 18. | IU1 | USP14 selective inhibitor | HeLa and SiHa cells (cervical cancer cells) | [210] |