Table 1.
Demographics, baseline parameters.
| Parameter | Mean ± SD 4; Median [IQR] 5 | N |
|---|---|---|
| Age (years) | 49.2 ± 17.1 | 109 |
| Male/Female | 63/46 | 109 |
| APACHE II score | 20.3 ± 9.5 | 89 |
| Predicted mortality (%) | 49.6 ± 26.8 | 89 |
| Comorbidities 1: | ||
| none | - | 43 (39.4) |
| biopsy confirmed cirrhosis | - | 33 (30.3) |
| confirmed portal hypertension | - | 37 (33.9) |
| past upper gastrointestinal bleeding | - | 18 (16.5) |
| previous liver failure | - | 19 (17.0) |
| previous hepatic encephalopathy | - | 16 (14.7) |
| other (cardiorespiratory, malignancy) | - | 48 (44.0) |
| SOFA 2 score T1 | 12.1 ± 4.3 | 89 |
| SOFA CNS 3 subscore | 1.3 ± 1.5 | 106 |
| SOFA cardiovascular subscore | 1.9 ± 1.7 | 106 |
| SOFA pulmonary subscore | 2.0 ± 1.6 | 97 |
| SOFA coagulation subscore | 1.8 ± 1.2 | 108 |
| SOFA liver subscore | 3.1 ± 1.2 | 108 |
| SOFA renal subscore | 2.1 ± 1.6 | 108 |
| Serum bicarbonate (mmol/L) | 19.8 ± 4.7 | 103 |
| Serum sodium (mmol/L) | 134.9 ± 8.0 | 108 |
| Serum potassium (mmol/L) | 3.9 ± 0.6 | 108 |
| Serum creatinine (mg/dL) | 1.8 ± 1.6 | 104 |
| Serum urea (pg/mL) | 14.6 ± 11.5 | 105 |
| Serum total bilirubin (mg/dL) | 12.0 (3.9–24.7) | 108 |
| Leukocytes (G/L) | 12.1 ± 7.2 | 107 |
| Platelets (G/L) | 98.1 ± 69.4 | 108 |
| C-reactive protein (mg/L) | 56.4 ± 68.8; 30.1 (14.0–81.9) | 85 |
| Procalcitonin (ng/mL) | 3.9 ± 6.4; 1.1 (0.6–4.3) | 64 |
| Interleukine-6 (pg/mL) | 136,558.5 ± 492,350.5; 149.9 (69.2–969.9) | 13 |
1 Number of patients with the registered comorbidity; 2 Sequential Organ Failure (SOFA) subscores range from 0 to 4 with an increasing score reflecting worsening of organ dysfunction; 3 CNS: central nervous system; 4 SD: standard deviation; 5 IQR: interquartile range.