Table 3.
Outcome parameters.
| Parameter | N | |
|---|---|---|
| Mortality at the end of hemoadsorption, n (%) | 10 (9.2) | 109 |
| ICU 1 mortality, n (%) | 60 (55.0) | 109 |
| Hospital mortality, n (%) | 65 (59.6) | 109 |
| ICU length of stay (days, median (IQR) 4) | 14.0 (7.0–23.0) | 107 |
| ICU length of stay—survivors (days, median (IQR)) | 16.0 (8.0–26.0) | 49 |
| ICU length of stay—non-survivors (days, median (IQR)) | 11.0 (7.0–21.0) | 58 |
| Mechanical ventilation (days, median (IQR)) | 5.0 (2.0–13.0) | 107 |
| Mechanical ventilation—survivors (days, median (IQR)) | 2.0 (0.0–7.0) | 49 |
| Mechanical ventilation—non-survivors (days, median (IQR)) | 8.0 (3.0–16.0) | 58 |
| Renal replacement therapy (days, median (IQR)) | 8.0 (4.0–14.0) | 107 |
| Renal replacement therapy—survivors (days, median (IQR)) | 6.0 (3.0–14.0) | 49 |
| Renal replacement therapy—non-survivors (days, median (IQR)) | 9.0 (5.0–14.0) | 58 |
| Days on vasopressors (median (IQR)) | 5.0 (2.0–11.0) | 106 |
| Days on vasopressors—survivors (median (IQR)) | 2.5 (0.0–8.5) | 48 |
| Days on vasopressors—non-survivors (median (IQR)) | 6.0 (4.0–11.0) | 58 |
| Change in SOFA 2 score (T2-T1), mean (CI) 5 | 0.5 (−0.3 to 1.3) | 73 |
| Change in SOFA CNS 3 subscore | 0.01 (−0.2 to 0.2) | 92 |
| Change in SOFA cardiovascular subscore | 0.1 (−0.3 to 0.4) | 95 |
| Change in SOFA pulmonary subscore | 0.04 (−0.2 to 0.2) | 85 |
| Change in SOFA coagulation subscore | 0.6 (0.4 to 0.8) | 90 |
| Change in SOFA liver subscore | −0.1 (−0.3 to 0.1) | 92 |
| Change in SOFA renal subscore | 0.1 (−0.3 to 0.5) | 94 |
| C-reactive protein at T2 (mg/L), mean ± SD 6; median (IQR) | 48.5 ± 55.3; 32.6 (13.0–70.8) | 69 |
| Procalcitonin at T2 (ng/mL), mean ± SD; median (IQR) | 5.9 ± 12.7; 1.4 (0.6–3.8) | 49 |
| Serum total bilirubin (mg/dL) at T2, median (IQR) | 8.7 (4.8 to 17.6) | 93 |
| Platelets at T2 (G/L), mean ± SD | 62.2 ± 59.4 | 91 |
| Interleukine-6 at T2 (pg/mL), mean ± SD; median (IQR) | 575.1 ± 1070.4; 237.7 (82.0–320.6) | 7 |
| Delta C-reactive protein (T2-T1) (mg/L), mean (CI) | −3.9 (−15.8 to 7.9) | 60 |
| Delta procalcitonin (T2-T1) (ng/mL), mean (CI) | 0.8 (−3.5 to 5.1) | 33 |
| Delta total bilirubin (T2-T1) (mg/L), mean (CI) | −4.6 (−6.3 to −2.8) | 92 |
| Delta platelet (T2-T1) (G/L), mean (CI) | −34.1 (−45.5 to −22.8) | 90 |
| Assessment of change due to hemoadsorption | 109 | |
| Improved, n (%) | 75 (68.9) | |
| No change, n (%) | 17 (15.6) | |
| Deteriorated, n (%) | 5 (4.8) | |
| Not assessed, n (%) | 12 (11.0) | |
1 ICU: intensive care unit; 2 Sequential Organ Failure (SOFA) subscores range from 0 to 4 with an increasing score reflecting worsening of organ dysfunction. 3 CNS: central nervous system; 4 IQR: interquartile range; 5 CI: 95% confidence interval; 6 SD: standard deviation.