Table 4.

DMCs of ENPP2 identified by comparing HCC and PC cell lines with a more (SKHEP1 and PC3 respectively) to less (HEPG2 and LNCAP respectively) invasive phenotype (GSE71627 dataset).

CG ID	Mβ Value 1 *	Mβ Value 2 *	Δβ Value #	Regulation	Gene Region	FDR
HCC
cg00320790	0.808	0.924	0.115	Up	Body	3.1 × 10−2
cg09444531	0.353	0.765	0.411	Up	Body	6.5 × 10−3
cg20048037	0.564	0.859	0.295	Up	Body	2.4 × 10−2
cg07236691	0.689	0.126	−0.563	Down	Body	3.6 × 10−3
cg04452959	0.339	0.784	0.444	Up	TSS200	5.1 × 10−2
cg02156680	0.472	0.868	0.396	Up	TSS1500	3.2 × 10−3
cg06998282	0.637	0.938	0.302	Up	TSS1500	1.8 × 10−4
cg02534163	0.710	0.967	0.257	Up	1st Exon	2.7 × 10−2
PC
cg00320790	0.574	0.900	0.326	Up	Body	2.3 × 10−3
cg07236691	0.778	0.824	0.046	Up	Body	5.6 × 10−2
cg09444531	0.251	0.585	0.333	Up	Body	4.3 × 10−3
cg20048037	0.370	0.671	0.301	Up	Body	8.8 × 10−3
cg20162626	0.190	0.552	0.362	Up	Body	1.7 × 10−2
cg26078665	0.662	0.772	0.110	Up	Body	2.3 × 10−3
cg02156680	0.725	0.377	−0.348	Down	TSS1500	2.5 × 10−3
cg02534163	0.772	0.951	0.179	Up	1st Exon	2.9 × 10−3

* Mean β (Mβ) value 1 represents methylation in less invasive cell lines and * Mean β (Μβ) value 2 methylation in more invasive; ^# Δβ value: (Mean β value 2-Mean β value 1). Abbreviations: PC: Prostate Cancer, HCC: Hepatocellular Carcinoma, PA: Promoter Associated, TSS: Transcription Start Site.