Table 4.
Dose frequency effect of ARB usage on dementia.
| Number | aHR * (95% CI) | p Value | Trend Test | |
|---|---|---|---|---|
| MPR ≤ 20% (reference) | 6322 | 1 | p = 0.005 | |
| 20% < MPR ≤ 30% | 798 | 0.791 (0.632–0.990) | 0.040 | |
| 30% < MPR ≤ 40% | 801 | 0.718 (0.573–0.899) | 0.003 | |
| 40% < MPR ≤ 50% | 798 | 0.713 (0.566–0.899) | 0.004 | |
| 50% < MPR ≤ 60% | 860 | 0.728 (0.587–0.902) | 0.003 | |
| 60% < MPR ≤ 70% | 915 | 0.538 (0.420–0.689) | <0.001 | |
| 70% < MPR ≤ 80% | 852 | 0.485 (0.375–0.626) | <0.001 | |
| MPR > 80% | 9862 | 0.704 (0.638–0.778) | <0.001 |
* Multivariable adjusting model is as the model 4 in Table 3. Abbreviation: ARB, angiotensin receptor blocker; MPR, medication possession ratio; aHR, adjusted hazard ratio; CI, confidence interval.