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. 2021 Nov 2;22(21):11881. doi: 10.3390/ijms222111881

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Viability of cultured E0771 cells after 24 h continuous treatment with Fasnall at the indicated concentrations (N = 12/group). (B) Orthotopic and ectopic E0771 tumor weights after 23 days of vehicle or Fasnall treatment (15 mg/kg, daily i.p. injections, N = 7–10/group, * p < 0.05 for the orthotopic vs. ectopic tumors in the vehicle group). The dashed lines indicate the division between Fasnall “non-responders” and “responders”. (C,D) Orthotopic and (E,F) ectopic E0771 tumor growth curves and tumor weights after 23 days of Fasnall treatment comparing vehicle with Fasnall “non-responders” and “responders” separately (* p < 0.05, ** p < 0.01 and *** p < 0.001 for vehicle vs. Fasnall). (G) Viability of cultured E0771 cells after three days of intermittent treatment (4 h/day) with Fasnall at the indicated concentrations (N = 10–12/group, ** p < 0.01 and *** p < 0.001 for control vs. Fasnall). Data are presented as mean ± SEM.

(A) Viability of cultured E0771 cells after 24 h continuous treatment with Fasnall at the indicated concentrations (N = 12/group). (B) Orthotopic and ectopic E0771 tumor weights after 23 days of vehicle or Fasnall treatment (15 mg/kg, daily i.p. injections, N = 7–10/group, * p < 0.05 for the orthotopic vs. ectopic tumors in the vehicle group). The dashed lines indicate the division between Fasnall “non-responders” and “responders”. (C,D) Orthotopic and (E,F) ectopic E0771 tumor growth curves and tumor weights after 23 days of Fasnall treatment comparing vehicle with Fasnall “non-responders” and “responders” separately (* p < 0.05, ** p < 0.01 and *** p < 0.001 for vehicle vs. Fasnall). (G) Viability of cultured E0771 cells after three days of intermittent treatment (4 h/day) with Fasnall at the indicated concentrations (N = 10–12/group, ** p < 0.01 and *** p < 0.001 for control vs. Fasnall). Data are presented as mean ± SEM.