Figure 2.

Locomotor activity in mice after injection of (a–c) methiopropamine (MPA) and (d–f) methamphetamine (MA). Locomotor activity was recorded for 240 min after i.p. injection of saline (0.9%), MPA (5–20 mg/kg) or MA (1–5 mg/kg). The results are expressed as (a,d) activity profiles of the mean distance travelled per 5 min intervals, (b,e) total run distance during the 240 min session and (c,f) maximum run distance (E_max) per 5 min intervals, n = 4–10. * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001 vs. saline (Dunnett’s post hoc test).