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Structure of human Nrf2 and Keap1. The high-affinity ETGE and low-affinity DLG motifs in the Neh2 domain of Nrf2 are bound by the Kelch domain of Keap1 for Nrf2 ubiquitination and degradation. ARE, antioxidant response element; BTB, broad-complex, tramtrack and bric-à-brac domain; CTR, C-terminal region; DGR or Kelch, double glycine repeat domain; IVR, intervening region; Neh, Nrf2-erythroid-derived CNC homology (ECH) domain; NTR, N-terminal region.
