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Final concentrations and respective targets of BRAFi/MEKi utilized in the experiments.
| Inhibitor/ Inhibitor Combinations |
Final Concentration | Target |
|---|---|---|
| vemurafenib (vemu, V) | 60 µM | BRAFV600E |
| dabrafenib (dabra, D) | 1 µM | BRAFV600E |
| trametinib (tram, T) | 30 nM | MEK 1/2 |
| cobimetinib (cobi, C) | 0.5 µM | MEK 1/2 |
