Table 4.
Clinical outcomes during the whole follow-up in the unmatched cohort of patients with AF and prevalent or incident HF with follow-up starting at the time of last event between AF or HF.
| Prevalent HF (n = 956,086) |
Incident HF (n = 393,552) | HR (95% CI) for Prevalent HF vs. Incident HF |
p (Uncorrected) | p (Bonferroni Correction) | |
|---|---|---|---|---|---|
| All-cause death | 316,729 (19.0) | 126,688 (21.8) | 0.91 (0.91–0.92) | <0.0001 | <0.0001 |
| Cardiovascular death | 117,294 (7.1) | 41,431 (7.1) | 1.04 (1.03–1.06) * | <0.0001 | <0.0001 |
| Non-cardiovascular death | 199,435 (12.0) | 85,257 (14.7) | 0.85 (0.84–0.86) | <0.0001 | <0.0001 |
| Ischemic stroke | 40,670 (2.5) | 14,266 (2.6) | 0.97 (0.95–0.99) † | 0.006 | 0.02 |
| Re-hospitalization for HF | 254,885 (19.3) | 45,877 (13.8) | 1.43 (1.42–1.45) | <0.0001 | <0.0001 |
| Cancer | 73,528 (4.7) | 25,214 (4.9) | 0.96 (0.94–0.97) | <0.0001 | <0.0001 |
* hazard ratio = 1.10 (1.08–1.11), uncorrected p < 0.0001, corrected p < 0.0001 by Fine and Gray model for competing risks of cardiovascular and non-cardiovascular death. † hazard ratio = 1.04 (1.02–1.06), uncorrected p < 0.0001, corrected p < 0.0001 by Fine and Gray model for competing risks of ischemic stroke and death. Values are n (incidence rate, %/year). AF, atrial fibrillation; CI, confidence interval; HF, heart failure; HR, hazard ratio.