Table 5.
Clinical outcomes during the whole follow-up in the matched cohort of patients with AF and prevalent or incident HF with follow-up starting at the time of last event between AF or HF.
| Prevalent HF (n = 212,293) |
Incident HF (n = 212,293) |
HR (95% CI) for Prevalent HF vs. Incident HF |
p (Uncorrected) | p (Bonferroni Correction) | |
|---|---|---|---|---|---|
| All-cause death | 68,150 (21.6) | 64,643 (19.3) | 1.10 (1.08–1.11) | <0.0001 | <0.0001 |
| Cardiovascular death | 24,156 (7.7) | 21,874 (6.5) | 1.14 (1.12–1.16) * | <0.0001 | <0.0001 |
| Non-cardiovascular death | 43,994 (14.0) | 42,769 (12.8) | 1.07 (1.06–1.09) | <0.0001 | <0.0001 |
| Ischemic stroke | 3775 (1.2) | 7824 (2.4) | 0.50 (0.48–0.52) † | <0.0001 | <0.0001 |
| Re-hospitalization for HF | 49,763 (19.4) | 24,785 (13.2) | 1.44 (1.41–1.46) | <0.0001 | <0.0001 |
| Cancer | 14,558 (4.9) | 15,176 (5.0) | 0.97 (0.95–0.99) | 0.005 | 0.02 |
* hazard ratio = 1.13 (1.11–1.16), uncorrected p < 0.0001, corrected p < 0.0001 by Fine and Gray model for competing risks of cardiovascular and non-cardiovascular death. † hazard ratio = 0.48 (0.46–0.50), uncorrected p < 0.0001, corrected p < 0.0001 by Fine and Gray model for competing risks of ischemic stroke and death. Values are n (incidence rate, %/year). AF, atrial fibrillation; CI, confidence interval; HF, heart failure; HR, hazard ratio.