Table 4.
Adjusted Cox proportional hazards analyses exploring associations of gene expression with outcomes.
| Composite Primary Endpoint | |||
| HR | 95% CI | p-Value | |
| FTMT Δct, T2 vs. T1 + T3 | 2.396 | 1.043–5.502 | 0.039 |
| SIRT71 Δct, T2 + T3 vs. T1 | 5.495 | 1.784–16.923 | 0.003 |
| SMIM20 Δct, T2 + T3 vs. T1 | 9.511 | 2.698–33.530 | 0.000459 |
| TFRC Δct, T3 vs. T1 + T2 | 1.042 | 0.347–3.126 | 0.942 |
| ADM Δct, T2 + T3 vs. T1 | 1.296 | 0.456–3.683 | 0.626 |
| ECE1 Δct, T2 + T3 vs. T1 | 1.489 | 0.588–3.767 | 0.401 |
| All-Cause Death | |||
| HR | 95% CI | p-Value | |
| FTMT Δct, T2 vs. T1 + T3 | 4.448 | 1.497–13.216 | 0.007 |
| SIRT71 Δct, T2 + T3 vs. T1 | 7.122 | 1.848–27.438 | 0.004 |
| SMIM20 Δct, T2 + T3 vs. T1 | 7.44 | 1.882–27.930 | 0.03 |
| TFRC Δct, T3 vs. T1 + T2 | 2.056 | 0.700–6.036 | 0.19 |
| ADM Δct, T2 + T3 vs. T1 | 1.497 | 0.460–4.869 | 0.502 |
| ECE1 Δct, T2 + T3 vs. T1 | 1.083 | 0.310–3.783 | 0.9 |
Adjusted Cox proportional hazards models using backwards methods. Δct (change in change in gene expression cycle threshold) gene expression tertiles according to generalized additive models of mRNA levels: T1 (lower expression), T2 (intermediate expression), T3 (higher expression). ADM (adrenomedullin), ECE1 (endothelin converting enzyme 1), FTMT (mitochondrial ferritin), TFRC (transferrin receptor), SMIM20 (small integral membrane protein 10), SIRT7 (sirtuin-7).