Table 6.
Univariate and multivariate logistic regression analysis of laboratory variables related to the presence of severe, moderate renal scars and borderline lesions in the scintigraphy. a. Univariate and multivariate logistic regression analysis of laboratory variables related to the presence of severe and moderate renal scars in the scintigraphy (n = 63). b. Univariate and multivariate logistic regression analysis of laboratory variables related to the presence of borderline lesions in the scintigraphy (n = 18).
| Variables | Univariate Regression Analysis | Multivariate Regression Analysis | ||
|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | |
| a | ||||
| Laboratory data | ||||
| Serum Cr (mg/dL) | 1.23 (0.15–9.90) | 0.841 | - | - |
| Cystatin C (mg/L) | 12.58 (1.62–97.58) | 0.014 | 7.09 (0.61–82.54) | 0.114 |
| GFR (mL/min/1.73 m2) | 0.97 (0.95–0.99) | 0.001 | 0.96 (0.94–0.98) | <0.001 |
| ACR (mg/g) | 1.03 (1.00–1.06) | 0.027 | 1.04 (1.00–1.07) | 0.053 |
| Urinary biomarkers | ||||
| TGF-β1 (ng/mL) | 0.85 (0.72–0.99) | 0.036 | 0.89 (0.73–1.08) | 0.225 |
| Endoglin (ng/mL) | 0.96 (0.89–1.05) | 0.374 | - | - |
| Periostin (ng/mL) | 1.28 (1.15–1.43) | <0.001 | 1.26 (1.12–1.40) | <0.001 |
| Cytokeratin-18 (ng/mL) | 12.93 (1.13–148.19) | 0.038 | 25.99 (1.25–539.35) | 0.033 |
| TGF-β1/Cr (ng/mg) | 0.99 (0.98–1.01) | 0.441 | - | - |
| Endoglin/Cr (ng/mg) | 0.90 (0.65–1.24) | 0.512 | - | - |
| Periostin/Cr (ng/mg) * | 1.05 (1.03–1.07) | <0.001 | - | - |
| Cytokeratin-18/Cr (ng/mg) | 1.13 (0.92–1.39) | 0.229 | - | - |
| b | ||||
| Laboratory data | ||||
| Serum Cr (mg/dL) | 14.23 (0.75–269.34) | 0.072 | - | - |
| Cystatin C (mg/L) | 35.80 (1.45–885.94) | 0.026 | 62.83 (1.65–2397.05) | 0.023 |
| GFR (mL/min/1.73 m2) | 0.97 (0.94–1.00) | 0.027 | 1.00 (0.96–1.04) | 0.055 |
| ACR (mg/g) | 1.00 (0.96–1.04) | 0.906 | - | - |
| Urinary biomarkers | ||||
| TGF-β1 (ng/mL) | 0.91 (0.75–1.11) | 0.343 | - | - |
| Endoglin (ng/mL) | 0.89 (0.78–1.01) | 0.077 | - | - |
| Periostin (ng/mL) | 1.20 (1.08–1.33) | 0.001 | 1.17 (1.05–1.31) | 0.005 |
| Cytokeratin-18 (ng/mL) | 14.48 (0.55–384.17) | 0.104 | - | - |
| TGF-β1/Cr (ng/mg) | 1.00 (0.98–1.02) | 0.939 | - | - |
| Endoglin/Cr (ng/mg) ** | 0.61 (0.38–0.98) | 0.038 | - | - |
| Periostin/Cr (ng/mg) | 1.01 (0.99–1.04) | 0.288 | - | - |
| Cytokeratin–18/Cr (ng/mg) | 0.95 (0.66–1.38) | 0.805 | - | - |
Cr—creatinine; GFR—estimated glomerular filtration rate; ACR—urinary albumin/creatinine ratio; TGF-β1—transforming growth factor-β1. * Periostin/Cr excluded from multivariate model due to collinearity. ** Endoglin/Cr excluded from multivariate model due to collinearity.