Table 7.
Diagnostic usefulness of laboratory variables for diagnosing severe, moderate renal scars and borderline lesions. a. Diagnostic usefulness of laboratory variables for diagnosing severe and moderate renal scars in the scintigraphy (n = 63). b. Diagnostic usefulness of laboratory variables for diagnosing renal borderline lesions in the scintigraphy (n = 18).
| Variables | AUC (95%CI) | p | Cut-Off | Sensitivity | Specificity |
|---|---|---|---|---|---|
| (%) | (%) | ||||
| a | |||||
| Laboratory data | |||||
| Serum Cr (mg/dL) | 0.503 (0.400–0.606) | 0.958 | 0.40 | 55.0 | 52.4 |
| Cystatin C (mg/L) | 0.624 (0.525–0.723) | 0.014 | 0.92 | 47.6 | 74.6 |
| GFR (mL/min/1.73 m2) | 0.678 (0.583–0.772) | <0.001 | 104.90 | 75.0 | 55.6 |
| ACR (mg/g) | 0.647 (0.550–0.744) | 0.003 | 16.40 | 56.5 | 68.3 |
| Urinary biomarkers | |||||
| TGF-β1 (ng/mL) | 0.630 (0.526–0.733) | 0.014 | 0.052 | 53.3 | 79.4 |
| Endoglin (ng/mL) | 0.579 (0.475–0.684) | 0.136 | 11.825 | 38.3 | 87.3 |
| Periostin (ng/mL) | 0.849 (0.780–0.918) | <0.001 | 0.053 | 84.1 | 75.0 |
| Cytokeratin-18 (ng/mL) | 0.611 (0.511–0.712) | 0.030 | 0.292 | 74.6 | 50.0 |
| TGF-β1/Cr (ng/mg) | 0.514 (0.410–0.618) | 0.791 | 0.092 | 60.0 | 50.8 |
| Endoglin/Cr (ng/mg) | 0.527 (0.423–0.632) | 0.606 | 6.794 | 87.5 | 23.8 |
| Periostin/Cr (ng/mg) | 0.810 (0.731–0.888) | <0.001 | 0.131 | 84.1 | 70.0 |
| Cytokeratin-18/Cr (ng/mg) | 0.580 (0.479–0.682) | 0.121 | 0.758 | 60.3 | 58.3 |
| b | |||||
| Laboratory data | |||||
| Serum Cr (mg/dL) | 0.625 (0.473–0.778) | 0.108 | 0.50 | 55.6 | 66.7 |
| Cystatin C (mg/L) | 0.645 (0.502–0.789) | 0.047 | 0.80 | 83.3 | 49.2 |
| GFR (mL/min/1.73 m2) | 0.669 (0.533–0.804) | 0.015 | 118.40 | 50.0 | 83.3 |
| ACR (mg/g) | 0.508 (0.341–0.676) | 0.922 | 4.51 | 81.7 | 33.3 |
| Urinary biomarkers | |||||
| TGF-β1 (ng/mL) | 0.566 (0.426–0.706) | 0.358 | 0.055 | 46.7 | 72.2 |
| Endoglin (ng/mL) | 0.661 (0.544–0.779) | 0.007 | 10.444 | 48.3 | 94.4 |
| Periostin (ng/mL) | 0.777 (0.642–0.911) | <0.001 | 0.086 | 66.7 | 86.0 |
| Cytokeratin-18 (ng/mL) | 0.626 (0.480–0.771) | 0.090 | 0.397 | 61.1 | 70.0 |
| TGF-β1/Cr (ng/mg) | 0.553 (0.396–0.710) | 0.506 | 0.043 | 73.3 | 55.6 |
| Endoglin/Cr (ng/mg) | 0.655 (0.491–0.818) | 0.064 | 5.496 | 92.9 | 44.4 |
| Periostin/Cr (ng/mg) | 0.658 (0.530–0.785) | 0.015 | 0.046 | 94.4 | 38.3 |
| Cytokeratin-18/Cr (ng/mg) | 0.532 (0.377–0.688) | 0.682 | 0.493 | 56.7 | 61.1 |
Cr—creatinine; GFR—estimated glomerular filtration rate; ACR—urinary albumin/creatinine ratio; TGF-β1—transforming growth factor-β1.