TABLE 2.

Geometric mean MICs and ranges of MICs of itraconazole after 24, 48, and 72 h

Species	No. of isolates	Medium	GMa (range) MIC (μg/ml)
			24 h	48 h	72 h
Aspergillus
A. flavus	27	RPMI	0.17 (0.03–0.25)	0.19 (0.03–0.25)	0.25 (0.06–0.5)
		RPMI-2	0.26 (0.06–0.5)	0.29 (0.06–0.5)	0.32 (0.125–0.5)
		AM3	0.17 (0.03–0.25)	0.22 (0.03–0.5)	0.25 (0.125–0.5)
A. fumigatus	26
General isolates	24	RPMI	0.28 (0.06–0.5)	0.42 (0.25–1)	0.47 (0.25–1)
		RPMI-2	0.3 (0.06–0.5)	0.4 (0.125–2)	0.49 (0.25–1)
		AM3	0.13 (0.03–0.25)	0.31 (0.125–0.5)	0.31 (0.25–0.5)
Itraconazole-resistant isolates	2	RPMI	2.83 (0.25–>16)	>16 (>16)	>16 (>16)
		RPMI-2	1.41 (0.5–4)	>16 (>16)	>16 (>16)
		AM3	0.35 (0.25–0.5)	2 (2)	2 (2)
A. niger	17	RPMI	0.24 (0.03–1)	0.42 (0.06–2)	0.59 (0.06–2)
		RPMI-2	0.29 (0.06–1)	0.44 (0.06–1)	0.52 (0.06–1)
		AM3	0.16 (0.03–0.5)	0.25 (0.03–1)	0.38 (0.06–1)
A. terreus	9	RPMI	0.1 (0.03–0.25)	0.17 (0.125–0.25)	0.17 (0.125–0.25)
		RPMI-2	0.15 (0.03–0.5)	0.2 (0.03–0.5)	0.25 (0.06–0.5)
		AM3	0.15 (0.03–0.25)	0.16 (0.03–0.25)	0.18 (0.03–0.25)
A. nidulansb	3	RPMI		0.5 (0.5)	0.5 (0.5)
		RPMI-2		0.5 (0.5)	0.5 (0.5)
		AM3		0.25 (0.25)	0.25 (0.25)
Fusarium
F. solani	18	RPMI	>16 (>16)	>16 (>16)	>16 (>16)
		RPMI-2	>16 (>16)	>16 (>16)	>16 (>16)
		AM3	>16 (>16)	>16 (>16)	>16 (>16)
F. oxysporum	4	RPMI	0.11 (0.03–0.25)	0.5 (0.5)	22.6 (8–>16)
		RPMI-2	0.42 (0.25–0.5)	0.5 (0.5)	19 (4–>16)
		AM3	0.15 (0.03–0.25)	0.35 (0.25–0.5)	1.41 (1–2)

^aGM, geometric mean. 

^bNo growth at 24 h.