TABLE 3.

Geometric mean MICs and ranges of MICs of voriconazole after 24, 48, and 72 h

Species	No. of isolates	Medium	GMa (range) MIC (μg/ml)
			24 h	48 h	72 h
Aspergillus
A. flavus	27	RPMI	0.16 (0.03–0.5)	0.25 (0.03–0.5)	0.36 (0.06–1)
		RPMI-2	0.19 (0.06–0.5)	0.29 (0.125–1)	0.35 (0.125–1)
		AM3	0.22 (0.06–0.5)	0.35 (0.125–0.5)	0.42 (0.125–0.5)
A. fumigatus	26
General isolates	24	RPMI	0.17 (0.125–0.5)	0.24 (0.125–0.5)	0.27 (0.125–0.5)
		RPMI-2	0.3 (0.125–0.5)	0.3 (0.125–0.5)	0.32 (0.125–1)
		AM3	0.18 (0.06–0.5)	0.26 (0.125–0.5)	0.34 (0.25–0.5)
Itraconazole-resistant isolates	2	RPMI	0.125 (0.125)	0.18 (0.125–0.25)	0.18 (0.125–0.25)
		RPMI-2	0.18 (0.125–0.25)	0.25 (0.125–0.5)	0.35 (0.25–0.5)
		AM3	0.09 (0.06–0.125)	0.25 (0.125–0.5)	0.25 (0.125–0.5)
A. niger	17	RPMI	0.11 (0.03–0.5)	0.24 (0.06–0.5)	0.32 (0.06–1)
		RPMI-2	0.15 (0.06–0.5)	0.35 (0.06–1)	0.42 (0.06–1)
		AM3	0.09 (0.03–0.5)	0.18 (0.125–0.5)	0.28 (0.125–1)
A. terreus	9	RPMI	0.16 (0.06–1)	0.25 (0.125–2)	0.37 (0.125–2)
		RPMI-2	0.17 (0.06–1)	0.32 (0.25–1)	0.4 (0.25–2)
		AM3	0.17 (0.125–0.25)	0.29 (0.125–0.5)	0.29 (0.125–0.5)
A. nidulansb	3	RPMI		0.5 (0.5)	0.5 (0.5)
		RPMI-2		0.5 (0.5)	0.5 (0.5)
		AM3		0.25 (0.25)	0.25 (0.25)
Fusarium
F. solani	18	RPMI	1.92 (0.25–4)	3.43 (1–8)	4.16 (1–8)
		RPMI-2	1.78 (0.25–4)	4 (1–16)	5.04 (1–16)
		AM3	0.76 (0.25–2)	1.78 (1–8)	3.05 (1–8)
F. oxysporum	4	RPMI	0.5 (0.25–1)	1.41 (1–2)	2 (1–4)
		RPMI-2	0.5 (0.5)	1.68 (1–4)	1.68 (1–4)
		AM3	0.84 (0.5–1)	1 (0.5–2)	1.41 (1–4)

^aGM, geometric mean. 

^bNo growth at 24 h.