TABLE 5.
Evaluation of MICs in AM3 compared to those in RPMI for Aspergillus and Fusariuma
| Drug and species | No. (%) of isolates for which MIC in AM3 is as follows compared to MIC in RPMIb:
|
||||
|---|---|---|---|---|---|
| ≥−2 | −1 | 0 | +1 | ≥+2 | |
| Amphotericin B | |||||
| Aspergillus | 24 (30.4) | 35 (44.3) | 16 (20.3) | 4 (5.1) | |
| Fusarium | 7 (31.8) | 8 (36.4) | 7 (31.8) | ||
| Itraconazole | |||||
| Aspergillus | 13 (16.4) | 20 (25.3) | 35 (44.3) | 10 (12.7) | 1 (1.3) |
| Fusarium | 21 (95.5) | 1 (4.6) | |||
| Voriconazole | |||||
| Aspergillus | 1 (1.3) | 13 (16.6) | 44 (55.7) | 20 (25.3) | 1 (1.3) |
| Fusarium | 8 (36.4) | 7 (31.8) | 5 (22.7) | 1 (4.6) | 1 (4.6) |
a
The MICs for 79 Aspergillus isolates and 22 Fusarium isolates which were readable after 24 h were analyzed.
b
≥−2, MIC in AM3 is twofold or more than twofold lower; −1, MIC in AM3 is onefold lower; 0, MIC in AM3 is identical to MIC in RPMI; +1, MIC in AM3 is onefold higher; ≥+2, MIC in AM3 is twofold or more than twofold higher.