Author response table 3.
| Basic model | Full model | |||
|---|---|---|---|---|
| Proportion mediated, % | Proportion mediated, % | Proportion mediated, % | Proportion mediated, % | |
| Smoking, no. of cigarettes/daycg08106661 | 26.80 | 0.038 | 28.50 | 0.036 |
| Diet score (ranging 0-6)cg21210537 | 3.89 | 0.256 | 4.66 | 0.206 |
| cg10643850 | -6.73 | 0.083 | -6.91 | 0.088 |
| cg05740632 | 11.03 | 0.062 | 11.30 | 0.068 |
| Body mass index, kg/m2cg20302171 | -2.90 | 0.269 | -2.87 | 0.267 |
| cg08484100 | -2.32 | 0.304 | -1.91 | 0.373 |
| Systolic blood pressure*, mmHg cg23398826 | 13.21 | 0.002 | 7.65 | 0.003 |
| cg13311494 | 3.14 | 0.082 | 15.61 | 0.031 |
| Diastolic blood pressure*, mmHg cg23398826 | 16.32 | 0.002 | 6.39 | 0.006 |
| cg13311494 | 3.80 | 0.079 | 12.38 | 0.045 |
| Total cholesterol, mmol/L cg26334131 | -5.67 | 0.449 | -31.62 | 0.168 |
| cg05740632 | -33.04 | 0.020 | -3.21 | 0.126 |
| cg21210537 | -6.70 | 0.169 | -8.19 | 0.197 |
| cg19583211 | 8.67 | 0.114 | 2.73 | 0.270 |
| Cholesterol in LDL, mmol/L cg26334131 | -3.25 | 0.406 | -32.14 | 0.135 |
| cg20302171 | -4.47 | 0.263 | -10.48 | 0.161 |
| cg05740632 | -17.77 | 0.032 | -3.38 | 0.110 |
| cg19583211 | 9.03 | 0.175 | 3.60 | 0.210 |
| cg13311494 | 9.02 | 0.177 | 3.70 | 0.208 |
| cg21210537 | -5.50 | 0.175 | -8.55 | 0.177 |
| Cholesterol in HDL, mmol/L cg15833447 | -3.69 | 0.293 | -10.77 | 0.180 |
| cg21210537 | 3.79 | 0.260 | 7.30 | 0.235 |
| Random blood glucose‡, mmol/L cg10400937 | 8.92 | 0.056 | 6.72 | 0.107 |
| cg01545454 | 6.08 | 0.122 | 9.58 | 0.097 |
| cg11754670 | 1.26 | 0.613 | 36.39 | 0.086 |
| cg26334131 | 1.50 | 0.612 | 32.70 | 0.109 |
| cg07219103 | 6.76 | 0.102 | 6.17 | 0.135 |
| cg20302171 | 2.49 | 0.397 | 15.77 | 0.123 |
* We added 15 and 10 mmHg to the measured systolic blood pressure and diastolic blood pressure respectively among participants who reported usage of blood pressure-lowering medications.
‡ Additionally adjusted for treatment of diabetes (yes or no) at baseline.